Correlations between innate gene modules and adaptive immune functional characteristics. (A) Expression data from genes that have been assigned to various innate modules were correlated with function characteristics including antibody titer and effector functions, Fc-receptor binding, and T- and NK-cell cytokines. The left 2 panels show correlations derived from the unadjuvanted group, with alum alone and alum/TLR4 or 7. The third and fourth panels show correlations derived from the unadjuvanted group, with MF59 alone and ANE/TLR4 or 7. Correlations that were common to all adjuvant groups are shown in the far-right panel. (B-E) Scatter plots show correlations for each group of vaccines between a representative gene module and either Ag-specific individual G2B glycan, rhesus Fc receptor 2A.4 binding, or 2A.3 binding. (B) Alum/TLR4; (C) alum/TLR7; (D) ANE formulations; (E) all adjuvant groups. For representative scatter plots, the correlation r_s and P values are displayed numerically; dashed lines indicate linear regressions; gray shading highlights the 95% confidence interval (CI).