American Society of Hematology

Figure 5.

T-cell subset responses post–VST infusion. (A) Median cell number for CD3+, CD4+, and CD8+ T cells for time points post–first VST infusion (× 109/L). (B) Median cell number for CD8+ T-cell memory subsets defined as T terminal effector (CD45RA+62L–), T naive (CD45RA+62L+), T central memory (CD45RA–62L+), and T effector memory (CD45RA–62L–). (C) Median cell number for the CD4+ T-cell memory subsets. (D) Percentage of CD8+ T cells expressing PD-1. Bars and lower and upper whiskers represent the median, 25th, and 75th percentiles, respectively. The results for healthy individuals at steady state are indicated by the dashed line (median) and gray shading (range).

T-cell subset responses post–VST infusion. (A) Median cell number for CD3⁺, CD4⁺, and CD8⁺ T cells for time points post–first VST infusion (× 10⁹/L). (B) Median cell number for CD8⁺ T-cell memory subsets defined as T terminal effector (CD45RA⁺62L^–), T naive (CD45RA⁺62L⁺), T central memory (CD45RA^–62L⁺), and T effector memory (CD45RA^–62L^–). (C) Median cell number for the CD4⁺ T-cell memory subsets. (D) Percentage of CD8⁺ T cells expressing PD-1. Bars and lower and upper whiskers represent the median, 25th, and 75th percentiles, respectively. The results for healthy individuals at steady state are indicated by the dashed line (median) and gray shading (range).

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