Figure 4.
Bcor mutations in NP23 pro–B-1 ALL. (A) Schematic of mouse Bcor transcript (Bcor-001; ENSMUST00000115513), exons 1 to 15. Black upper-case text is exon 8 coding sequence. Underlined sequence indicates PCR primers. An internal alternative exon 8 splice acceptor site is indicated (|). The Bcor 11-bp palindromic mutational hotspot is shown in red. (B) Bcor exon 8 mutations at the exon 8 hotspot; indels shown in red capital letters. (C) WT and 724 pro–B-1 ALL sequence across the mutational hotspot (underlined). Red arrow indicates site of CC dinucleotide insertion. (D) 724 messenger RNA expression (lower panel). Red arrows indicate CC dinucleotide insertion. Predicted amino acid sequence is indicated (upper panel). (E) Schematic of the mouse Bcor protein and mutation sites (arrowheads).

Bcor mutations in NP23 pro–B-1 ALL. (A) Schematic of mouse Bcor transcript (Bcor-001; ENSMUST00000115513), exons 1 to 15. Black upper-case text is exon 8 coding sequence. Underlined sequence indicates PCR primers. An internal alternative exon 8 splice acceptor site is indicated (|). The Bcor 11-bp palindromic mutational hotspot is shown in red. (B) Bcor exon 8 mutations at the exon 8 hotspot; indels shown in red capital letters. (C) WT and 724 pro–B-1 ALL sequence across the mutational hotspot (underlined). Red arrow indicates site of CC dinucleotide insertion. (D) 724 messenger RNA expression (lower panel). Red arrows indicate CC dinucleotide insertion. Predicted amino acid sequence is indicated (upper panel). (E) Schematic of the mouse Bcor protein and mutation sites (arrowheads).

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