Relationship between InO PK parameters and MRD status. (A) Box plots of dose normalized (dn) values of median C_max and C_min by cycle (1 to 4) and by achievement of MRD negativity (yes vs no). Boxes correspond to the 25% and 75% percentiles; whiskers extend to the most extreme data point that is no more than 1.5 times the length of the box away from the box. Red points represent potential outliers and correspond to individual values >1.5 times the interquartile range above or below the respective quartile. (B) Relationship between percentage BM blasts at baseline and achieving MRD negativity for individual patients. Green and blue plots correspond to patients achieving and not achieving MRD negativity, respectively. (C) The 5 panels show serum InO concentration vs time by MRD-negativity status for dosing at cycle 1 day 1 and 15, cycle 2 days 1 and 15, and cycle 4 day 1. Symbol sizes represent percent leukemic blasts in BM.