Figure 7.
![Figure 7. Hmga2 inhibition ameliorates MPN in JAK2V617F mice with Ezh2 KO. (A) Schematic diagram of Hmga2 KO (Hmga2−/+) in JAK2V617F/EZH2fl°x/WT/CRE-ERT (JE). BM cells were collected from JE with HMGA2−/+ (JEH) or HMGA2+/+ (JE) mice and transplanted. Conditional Ezh2 KO was initiated by tamoxifen 4 weeks after transplantation. (B) Complete blood cell counts (means ± SEM). N = 5 for each. *P < .05; **P < .01; ***P < .001 (Student t test). (C) Spleens at 8 weeks after transplantation with JE, JEH, JE without Cre [JE(Cre−)], and JEH without Cre [JE(Cre−)H] cells. Left, Representative figure. Right, Mean spleen weight. N = 3 for each; ***P < .001 (Turkey-HSD test).](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/1/15/10.1182_bloodadvances.2017004457/3/advances004457f7.jpeg?Expires=1724180536&Signature=WV~RXIQGxoat9fZp1kGQ5CA~RvqwKHdiSjxLvXmFYkhb6DUifIzpBJETPcq~9KPfwd1TRwpUJr6pM3lE6HHR18wuJPTyqtTmzujh~irL-UJJGO8rWrzOSkTfp~xbgL9b59EPKBhJDqEZAeVz-lx~Cd8UcMPKlw0W~wepiF5MvdppU7LCcPbpXB1R9EblghfUzkzL-6tPyWRl2T14ll8RpahdPmVaL8p2itLzmA6MyeQ0AqF9Olf4jaWOo9V7NbP~ooQlzTfJI7c8DVg2kCq3aar~T7V8AGQw~5pyrz1A-ZxrtwBoXo7AvAZvYEGiGrY2FO7~vtNiv4BUHllCNN7NjA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Hmga2 inhibition ameliorates MPN in JAK2V617Fmice with Ezh2 KO. (A) Schematic diagram of Hmga2 KO (Hmga2−/+) in JAK2V617F/EZH2fl°x/WT/CRE-ERT (JE). BM cells were collected from JE with HMGA2−/+ (JEH) or HMGA2+/+ (JE) mice and transplanted. Conditional Ezh2 KO was initiated by tamoxifen 4 weeks after transplantation. (B) Complete blood cell counts (means ± SEM). N = 5 for each. *P < .05; **P < .01; ***P < .001 (Student t test). (C) Spleens at 8 weeks after transplantation with JE, JEH, JE without Cre [JE(Cre−)], and JEH without Cre [JE(Cre−)H] cells. Left, Representative figure. Right, Mean spleen weight. N = 3 for each; ***P < .001 (Turkey-HSD test).
