![Figure 1. Progressive MPN in ΔHmga2/JAK2V617F mice. (A) Schematic diagram of the experiment. WT, ΔHmga2 (H), JAK2V617F (J), and ΔHmga2/JAK2V617F (HJ) mice were obtained in predicted Mendelian ratios. The analyses were performed at 12 weeks old. (B) Complete blood cell counts (means ± standard error of the mean [SEM]) and (C) fractions of white blood cells (%) in 5 WT, 7 H, 5 J, and 4 HJ mice. *P < .05; **P < .01; ***P < .001 calculated by the Tukey-HSD test. (D) May-Giemsa stains of peripheral blood samples (original magnification ×1000). Scale bars indicate 50 µm. (E) Survival periods. N = 9 for WT, 9 H, 12 J, and 7 HJ mice. The P values were calculated by a log-rank test. Bas, basophil; Eos, eosinophil; Hb, hemoglobin concentration (g/dL); Lym, lymphocyte; Mon, monocyte; Neu, neutrophil; OS, overall survival; PLT, platelet count (×1011/L); RBC, red blood cell count (×1012/L); WBC, white blood cell count (×109/L).](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/1/15/10.1182_bloodadvances.2017004457/3/advances004457f1.jpeg?Expires=1724179033&Signature=OzgTIIQJtfeBokNHYy2~BpCkAf9L~3-titZxcaHm~KO4eLr2lR39m0BSpm28fnSpbfFWZEKJVioUZGQzXr2tzZ-piEngYhbykMGdGKR6SDRWpABTXFProjMHmjlZllrtgxwhgzHwFftD-kp-zCGc0jfDuKfYCPy6ybtkaGyajAJ0jrJcY7meNARYllDKRRoQa4ErLx73oSkgYd8VN981CugRbm7dDoDLWk0DTKWNSJx~OK8W5d~G9L06JuJYSEyudjnkRX-gjdfUSmBq5-mV5j8VM4T7eFvTKKgKz-nkQfvO3FKJVaQqkK6cHuL0k6Y1WZCbdtelh9l1f0nGtZfzWA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Progressive MPN in ΔHmga2/JAK2V617Fmice. (A) Schematic diagram of the experiment. WT, ΔHmga2 (H), JAK2V617F (J), and ΔHmga2/JAK2V617F (HJ) mice were obtained in predicted Mendelian ratios. The analyses were performed at 12 weeks old. (B) Complete blood cell counts (means ± standard error of the mean [SEM]) and (C) fractions of white blood cells (%) in 5 WT, 7 H, 5 J, and 4 HJ mice. *P < .05; **P < .01; ***P < .001 calculated by the Tukey-HSD test. (D) May-Giemsa stains of peripheral blood samples (original magnification ×1000). Scale bars indicate 50 µm. (E) Survival periods. N = 9 for WT, 9 H, 12 J, and 7 HJ mice. The P values were calculated by a log-rank test. Bas, basophil; Eos, eosinophil; Hb, hemoglobin concentration (g/dL); Lym, lymphocyte; Mon, monocyte; Neu, neutrophil; OS, overall survival; PLT, platelet count (×1011/L); RBC, red blood cell count (×1012/L); WBC, white blood cell count (×109/L).
