Analysis of CNAs in 3 patients with t-MNs. (A) CNAs detected in t-MN BM samples and matching prior PB samples from each patient. Vertical axis represents log2 ratio of copy number, and horizontal axis represents each chromosome. Y chromosome is not shown because 295-gene panel sequencing does not have enough coverage to analyze CNA in the chromosome. Each chromosome area that showed statistically significant CNA is magnified below, and z score is indicated. (B) Inferred model of clonal architecture and evolution from CHIP to t-MNs. Model was generated based on the estimated clonal fraction of CNAs and point mutations. Chr 7, chromosome 7.