Proposed model of GL-2045–complement interactions. (A) GL-2045 binds to and sequesters C1q, thus preventing the activation of classical pathway at the site of inflammation. (B) GL-2045 also induces early activation of the classical pathway, resulting in the formation of C4bC2b. Although this molecule can cleave C3, the ability of GL-2045 to potentiate degradation of C3b to iC3b by factors H and I in combination and disassociation of C3bBb by factor H inhibits the C3 convertase amplification loop and the C5 convertases.