Impact of MRD on patient outcome in patients who have achieved conventional CR. Impact of MRD on PFS was evaluated in 14 studies (1273 patients) and on OS in 12 studies (1100 patients) overall, including the impact of MRD on PFS in 5 studies (574 patients) (A) and OS in 6 studies (616 patients) (B) in the setting of conventional CR. MRD negativity was associated with improved PFS and OS, both overall (P < .001) and in patients who were in CR (P < .001).³⁸  Modified from Munshi et al³⁸  with permission.