Figure 2.
PK and PD of emicizumab during once-weekly subcutaneous administrations of emicizumab. Mean (± standard deviation) time courses of plasma emicizumab concentration (A), aPTT (B), peak height of FXIa-triggered TG (C). The reference ranges for aPTT and peak height of FXIa-triggered TG are 25.4 to 37.2 seconds and 341 to 489 nmol/L, respectively, which were derived from healthy Japanese participants.22 All data collected after dose up-titrations were excluded; the number of patients for this summary was 6 per cohort. Data points where the number of patients with quantifiable measurement was ≥2 and not less than half of the number of observed patients were plotted.
