Number of synonymous and nonsynonymous mutations in patients with high-risk smoldering myeloma or newly diagnosed MM. The upper whisker extends from the hinge to the highest value that is within 1.5 × the interquartile range (IQR) of the hinge, in which the IQR is the distance between the first and third quartiles. The lower whisker extends from the hinge to the lowest value within 1.5 × IQR of the hinge. Data beyond the ends of the whiskers are outliers and are plotted as points (as specified by Tukey). The total number of mutations in high-risk smoldering myeloma (n = 15) was 3012, the median number per patient was 178 (IQR, 137-239), the median number of synonymous mutations per patient was 135 (IQR, 106-175), and median number of nonsynonymous mutations per patient was 34 (IQR, 30-58). Total number of mutations in newly diagnosed multiple myeloma (n = 40) was 8122, the median number of mutations per patient was 169 (IQR, 139-236), the median number of synonymous mutations per patient was 128 (IQR, 107-176), and the median number of nonsynonymous mutations per patient was 40 (IQR, 28-54). The blue horizontal bars represent the median number of mutations.