Near-tetraploidy is associated with Richter transformation on ibrutinib. (A) Cumulative incidence curves for transformation on ibrutinib with and without near-tetraploidy. (B) Cumulative incidence curves for transformation by near-tetraploidy and complex karyotype status. (C) Kaplan-Meier curves of OS for patients with or without near-tetraploidy. (D) Kaplan-Meier curves of OS by near-tetraploidy and complex karyotype status.