Figure 3.
Effect of anfibatide on human platelet adhesion and aggregation on a collagen surface under flow. (A-B) Representative images of platelet coverage and the rate of platelet accumulation on a collagen surface over time, respectively, after perfusion (50 dyne/cm2) of anticoagulated normal whole blood (n = 4) in the absence or presence of anfibatide (1.5 µg/mL). (C-D) Representative images of platelet coverage at the end of 3 minutes and the rate of platelet accumulation on a collagen surface, respectively, after perfusion (50 dyne/cm2) of an anticoagulated TTP patient’s whole blood, in the absence (buffer) or presence of 2 different concentrations (0.75 and 1.5 µg/mL) of anfibatide. The photomicrographs shown are 44% of the original size.
