Effect of anfibatide on murine platelet adhesion and aggregation on a collagen surface under flow. (A-B) Representative images of platelet coverage at the end of 3 minutes and the rate of platelet accumulation on a collagen surface over time (means/standard error of the mean [SEM], n = 4), respectively, after perfusion (50 dyne/cm²) of anticoagulated murine (Adamts13^−/−) whole blood in the presence of PBS (buffer) or anfibatide (1.5 μg/mL). (C-D) Representative images of platelet coverage at the end of 3 minutes and the rates of platelet accumulation on a collagen surface over time (mean/SEM, n = 3), respectively, after perfusion of anticoagulated whole blood obtained from Adamts13^−/− mice 6 hours after an intraperitoneal administration of anfibatide 60 ng/g body weight. The photomicrographs shown are 44% of the original size.