Myelofibrosis-free survival curves. (A) Myelofibrosis-free survival in 133 Mayo Clinic patients with PV stratified by the presence or absence of “adverse” (ASXL1, SRSF2, IDH2) DNA sequence variants/mutations. (B) Myelofibrosis-free survival in 215 Italian patients with PV stratified by the presence or absence of adverse variants/mutations. (C) Myelofibrosis-free survival in 183 Mayo Clinic patients with ET stratified by the presence or absence of “adverse” (SH2B3, IDH2, SF3B1, U2AF1, EZH2, TP53) sequence variants/mutations. (D) Myelofibrosis-free survival in 174 Italian patients with ET stratified by the presence or absence of adverse sequence variants/mutations.