Figure 2.
![Figure 2. The open chromatin state of protein coding genes and miRNAs changes dynamically in HSCs. (A) Classification of the genomic features in an open chromatin configuration as determined by our ATAC-seq analysis. TTS, transcription termination site. (B) The overlap of genes with an open chromatin configuration in their promoter-TSS region among LT-HSCs, ST-HSCs, and MPPs. (C) Heat map showing enrichment (-log10 [FDR]) of GO terms in gene set with ATAC-seq peaks found in their promoter regions. (D) Heat map of ATAC-seq peak scores ranking by LT-HSCs for the promoter-TSS regions of miRNAs. FDR, false discovery rate.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/1/14/10.1182_bloodadvances.2016003384/3/advances003384f2.jpeg?Expires=1724238119&Signature=SQpUzyWz0F-GyCr~Wkxo~VQTh1dEzg~5-1fewRzxj3~lgJW15n-03vLlIA0mKvb7pIpCvDwm1ABRudysnTrXUvzqZuebSX3TD~~LPO-T0UjehtQf~aJnWExgYZ8WqrhTy5iiorNZOyqaM4Dv5etZFqM6i0225zzu3rMrJTi62I63WbPldDIYl1mAZYaCBy2-ioKYqY-si4mzymHER0S6b9-qt~B2ZHw5xC3D4V0ppdzrBr~dL6XXMlhXFn8Gub~qJhDkhZUwNps01jsGU4PtMq4xu~JVDWpwA8WkQ6eRx5XYvwJcu26xcs091nL0rTAw-~sr33~3hGg2uj83C0yiqw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The open chromatin state of protein coding genes and miRNAs changes dynamically in HSCs. (A) Classification of the genomic features in an open chromatin configuration as determined by our ATAC-seq analysis. TTS, transcription termination site. (B) The overlap of genes with an open chromatin configuration in their promoter-TSS region among LT-HSCs, ST-HSCs, and MPPs. (C) Heat map showing enrichment (-log10 [FDR]) of GO terms in gene set with ATAC-seq peaks found in their promoter regions. (D) Heat map of ATAC-seq peak scores ranking by LT-HSCs for the promoter-TSS regions of miRNAs. FDR, false discovery rate.
