Figure 4.
Figure 4. Distribution of human ILCs in BRGSF mice and effect of Flt3L treatment. (A) Representative flow cytometry analysis of CD3−CD5−EOMES−CD7+CD127+ innate lymphoid cells in spleen, liver, and lung and CD3−CD5−CD94−CD7+CD127+ cells in gut of an Flt3L-treated BRGSF mouse. (B) Comparative quantification of ILCs in spleen, lung, liver, and gut of BRGSF mice treated or not with Flt3L as a percentage of hCD45+ cells (top) and total number of cells (bottom). Composite data from of 14 mice per condition in 4 experiments are shown. Each dot represents 1 mouse. Numbers in plots represent frequencies within gates.

Distribution of human ILCs in BRGSF mice and effect of Flt3L treatment. (A) Representative flow cytometry analysis of CD3CD5EOMESCD7+CD127+ innate lymphoid cells in spleen, liver, and lung and CD3CD5CD94CD7+CD127+ cells in gut of an Flt3L-treated BRGSF mouse. (B) Comparative quantification of ILCs in spleen, lung, liver, and gut of BRGSF mice treated or not with Flt3L as a percentage of hCD45+ cells (top) and total number of cells (bottom). Composite data from of 14 mice per condition in 4 experiments are shown. Each dot represents 1 mouse. Numbers in plots represent frequencies within gates.

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