Comparison of asparaginase dose and 3-year cumulative incidence of pancreatitis in different protocols. Native E. coli-asparaginase (E.coli-ASP) and PEG-asparaginase (PEG-ASP) were given intramuscularly at doses shown in the table. *Total dose of native E.coli-ASP (excluding the Extended Induction phase), according to protocol. PEG-ASP administration at 2,500 U/m2 is considered equivalent to native E. coli-ASP at 50,000 U/m². ^#Dichotomized by total dose of native E.coli-ASP (or equivalent dose of PEG-ASP) above or below 240,000 U/m². Abbreviations: ASP, asparaginase.