demonstrates CLLU1 levels normalized to pretreatement levels in relationship to MRD assessment by 4-color flow from the marrow on log scales. CLLU1 levels in the blood correlate with MRD monitoring in marrow over serial evaluations at different therapeutic assessments. CLLU1 levels in the blood begin to increase along with relapse of MRD in the marrow (0.4%) prior to evidence of clinical relapse.