Sensitivity of Bcr-Abl kinase domain mutants to Abl kinase inhibitors.

Imatinib: sensitive (≤ 1000 nM), intermediate (≤ 3000 nM), insensitive (> 3000 nM).

Nilotinib: sensitive (≤ 50 nM), intermediate (≤ 500 nM), insensitive (> 500 nM).

Dasatinib: sensitive (≤ 3 nM), intermediate (≤ 60 nM), insensitive (> 60 nM).

* The IC₅₀ value is the concentraion of inhibitor resulting in a 50% reduction in cell viability. For experimental details, see references ^8,12,21,29.

† IC₅₀ values from Burgess et al, PNAS 2005.²¹

‡ IC₅₀ values from Shah et al, Cancer Cell 2002.²⁹

§ IC₅₀ values estimated from Shah et al, Science 2004.⁸