Schematic representation of the structure and mutations in thePIGAgene. Coding region is shown in boxes, introns in form of dashes (not in scale), nucleotide numbers are shown above the exons. Null mutations (frame-shift, nonsense and splicing) are indicated above. Missense mutations and in-frame mutations are shown below. All mutations are somatic mutations with the exception of polymorphism shown in green.

Reproduced with permission from Luzzatto L and Nafa K. Genetics of PNH. In: Young NS, Moss J, eds. PNH and the GPI-linked Proteins. San Diego: Academic Press; 2000:21–47.