The glycosyl phosphatidylinositol anchor. This illustration, drawn by Dr. Martin Low, accompanied a News and Views article published in Science in 1985.³⁶ The figure legend, authored by Dr. Low, but excluded from the article, read as follows: “A protein molecule is covalently attached to a phosphatidylinositol molecule situated in the membrane. Cleavage of the phosphatidylinositol by phospholipase C releases the protein from the membrane.” The publicity from this article lead to discovery that all of proteins that are deficient in PNH are anchored to the cell surface by means of this glycosyl phosphatidylinositol moiety.
 Reproduced from

by copyright permission of the American Association for the Advancement of Science.