(A) Pyrvinium induces apoptosis of BP-CML CD34⁺ but not CB CD34⁺ cells and combination of pyrvinium and dasatinib is superior in inducing apoptosis. Pyrvinium is more effective in decreasing colony formation (B) and serial replating capacity (C) in BP-CML CD34⁺ than CB CD34⁺ cells. The combination is significantly more effective than single drug treatment (* p<0.01). (D) Pyrvinium is effective in vivo and significantly enhances the tumour growth inhibition of dasatinib (* p<0.01).