Figure 1:
Enhanced AF inducibility and prolonged AF duration in TMpro/pro mice. Transesophageal stimulation was used to test AF inducibility. A surface electrocardiogram (lead I, sampled at 2.5 kHz) was recorded to detect AF. A) Traces show an example of a Wt mouse, returning to normal sinus rhythm immediately after the burst (upper panel) and a TMpro/pro mouse, showing a 3s episode of AF before returning to sinus rhythm (lower panel). In both cases, the first P wave observed after the burst is indicated. B) AF was inducible in 1 out of 10 Wt mice and 6 out of 10 TMpro/pro mice. C) Distribution of the longest AF episode duration observed in each Wt and TMpro/pro mouse.
