Figure 1: Achieved FVIII plasma levels in adults (1A and 1C) and children (1B and 1D) receiving FVIII clotting factor replacement therapy. Figure 1A and 1B: Achieved FVIII plasma levels of patients treated by continuous infusion (blue dots) and by bolus infusions (red dots). Figure 1C and 1D: Achieved FVIII plasma levels of patients treated for a medium risk surgical procedure (blue dots) and patients treated for a low risk surgical procedure (red dots). Predefined target levels (green line) as stated by the Dutch Hemophilia Consensus are depicted as green boxes (Leebeek et al. 2009)