Predicted FVIII activity over time for patients that treat a bleeding episode with rFVIIIFc (25 IU/kg) 24 hours before a scheduled prophylactic dose on regimens of: A) 50 IU/kg E4D; and, B) 50 IU/kg E3D. Based on incremental recovery observed in A-LONG, a rFVIIIFc dose of 25 IU/kg is expected to increase factor activity by approximately 50 IU/dL.