Volcano plot of differentially methylated genes, plotting difference of means against the −log(10) of the respective p-value. The cutoff for the definition for significant differentially methylated probes was set at a difference of means >1.5 or < −1.5 and a p-value < 0.001. Hypomethylated probes are depicted in green, hypermethylated probes in red. The respective numbers are documented in the same color. A) comparison of normal plasma cells with MGUS. B) comparison of normal plasma cells with newly diagnosed MM. C) comparison of normal plasma cell with relapsed myeloma