MD snapshots of dasatinib (green, left) and AP24534 (orange, right) bound to BCR-ABL1^T315I/V299L. The two inhibitors are depicted in stick-and-ball representation, whilst the 3D structure of the kinase is shown as a transparent ribbon. All residues strongly involved in drug binding are highlightedas green/orange colored sticks respectively.The two mutant residues (1315 and L299)are highlighted inlight blue. Note the higher steric clash (light blue areas) in the case of dasatinib, accounting for the very low affinity of the drug for this double mutant. Hydrogenatoms, water molecutes and ions are omitted for clarity.