The t(14;18) translocation and expression of the BCL2 protein. Schematic representations show the germline configuration of the BCL2 gene as well as the chromosomal breakpoints involved in the t(14;18)(q21;q32) translocation. The BCL2 protein is absent in normal germinal center B-cells whereas it is expressed in the neoplastic follicles of follicular lymphoma, as shown by immunohistologic staining for the BCL2 protein.