Modeling of folate-conjugated dendrimer nanostructure. Folate is exposed on the surface of the amine-surfaced polymer (left panel), but non-specific interactions between surface amines and cell dendrimers (middle panel) lacked non-specific interactions; however, the acetimide was predicted to have the folate in a surface position that was likely to interact with receptors on cells. This was proven to be correct in studies with intact cells expressing the receptor.