Kaushansky Figure 1.
Kaushansky Figure 1. The structure of EPO-R in the absence and presence of an activating ligand. . / The α-carbon trace of the extracellular domain of EPO receptor in the absence (A) and presence (B) of an activating EPO mimetic peptide (EMP) is shown, along with a cartoon representation of the intracytoplasmic events that ensue upon ligand binding. / J2i indicates inactive JAK2; J2a, active JAK2. / Adapted from Livnah et al24 and reproduced with permission. Copyright 1999 AAAS.

The structure of EPO-R in the absence and presence of an activating ligand.

The α-carbon trace of the extracellular domain of EPO receptor in the absence (A) and presence (B) of an activating EPO mimetic peptide (EMP) is shown, along with a cartoon representation of the intracytoplasmic events that ensue upon ligand binding.

J2i indicates inactive JAK2; J2a, active JAK2.

Adapted from Livnah et al24 and reproduced with permission. Copyright 1999 AAAS.

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