Figure 2:
Figure 2:. Regulation of the hepatic heme biosynthetic pathway and subcellular localization of the enzymes of the pathway. . / Schematic of the synthesis of heme and its regulation. The regulatory heme pool acts to stimulate (+) or down-regulate (−) the indicated steps. Those steps indicated as not within the nucleus or mitochondrion take place in the cytosol. The dashed line indicates a still controversial regulatory effect of heme to decrease transcription of the gene of ALA synthase 1. / Abbreviations: ALA, 5-aminolevulinate; CO, carbon monoxide; CoA, coenzyme A; PBG, porphobilinogen. / Reprinted from Chemmanur AT, Bonkovsky HL. Hepatic porphyrias: diagnosis and management. Clin Liver Dis. 2004;8:807–838, with permission from Elsevier.

Regulation of the hepatic heme biosynthetic pathway and subcellular localization of the enzymes of the pathway.

Schematic of the synthesis of heme and its regulation. The regulatory heme pool acts to stimulate (+) or down-regulate (−) the indicated steps. Those steps indicated as not within the nucleus or mitochondrion take place in the cytosol. The dashed line indicates a still controversial regulatory effect of heme to decrease transcription of the gene of ALA synthase 1.

Abbreviations: ALA, 5-aminolevulinate; CO, carbon monoxide; CoA, coenzyme A; PBG, porphobilinogen.

Reprinted from

Chemmanur AT, Bonkovsky HL. Hepatic porphyrias: diagnosis and management.
Clin Liver Dis
.
2004
;
8
:
807
–838, with permission from Elsevier.

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