Enrichment of peripheral blood RBC chimerism compared with WBC chimerism in the blood, hematopoietic organs, and stem cells.21 (A) In the individual mice, a striking enrichment of peripheral blood RBC versus WBC chimerism occurred. (B) Enrichment of peripheral RBC chimerism (x-axis) compared with WBC chimerism (y-axis) in the bone marrow and spleen occurred in mice that received transplants. (C) Enrichment of peripheral RBC chimerism (x-axis) compared with stem cell chimerism (y-axis) in the bone marrow and spleen also occurred in the mice that received transplants. (D) A higher percentage of splenic stem cells than bone marrow stem cells were donor derived in the chimeric mice. The line depicts the theoretical 1:1 ratio of bone marrow to spleen stem cells.
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