Model of DIAPH1/mDia1 deletion in del(5q) MDS. Deletion of mDia1, a chromosome 5q gene, results in overexpression of CD14 in granulocytes. Overexpression of CD14, a coreceptor for TLR4, leads to increased TLR4 signaling in granulocytes, granulocytopenia, and BM dysplasia.