Time to CNS disease in patients with craniofacial involvement. (A) Patients receiving intrathecal prophylaxis with MTX prophylaxis or not. (B) Patients receiving radiotherapy or not. (A) There was no difference with respect to the rate of CNS disease between 88 patients with craniofacial involvement who received MTX prophylaxis (gray curve) and 191 patients who did not (black curve; P = .981). (B) Similarly, there was no difference in CNS incidence between 144 who received radiotherapy (gray curve) and 57 who did not (black curve; P = .205).