(A) Virus is bound by platelets and internalized. (B) Viral particles are degraded, releasing ssRNA, which binds TLR7, and initiating signaling through Akt and p38–mitogen-activated protein kinase (MAPK). (C) Platelet activation results in morphological changes and release of α-granules, leading to increased expression of molecules such as P-selecting on the platelet surface. (D) Activated platelets bind to leukocytes in the circulation such as neutrophils. (E) Bound platelets (or fragments derived from bound platelets) are then phagocytosed by the neutrophil.