Composition and mechanism of action of a new “designed” graft. It contains a megadose of CD34⁺ cells that are depleted of TCRαβ⁺/CD19⁺ cells plus adoptive immunotherapy with FoxP3Tregs and Tcons in an established ratio of 2:1. Besides the GVL effect, Tcons, NK cells, and TCRγδ⁺ T cells hasten immune reconstitution.