Outcome by cohort and IKZF1 status. DFS, CIR, and OS curves by IKZF1 status in the pre-TKI cohort (A, B, and C, respectively) and in the EsPhALL cohort (D, E, and F, respectively), with 4-year estimates (SE). Three additional events occurred after more than 4 years from CR1 (2 relapses in IKZF1-deleted patients and 1 relapse in wild-type), and are therefore not depicted in the plots of A and B. Two deaths that occurred after more than 4 years from CR1 in wild-type, relapsed pre-TKI patients are not depicted in C. CR1, first complete remission.