Somatic deletions identified on chromosome 6 by WGS in WM patients. (A) Frequency of statistically significant chromosome 6 deletions from the 10 paired patients highlighting genes of interest. The positions of the deletions are mapped against chromosome 6 cytogenetic bands. (B) Relative coverage across chromosome 6 for each of the 10 paired samples. Losses in 6q were not always single contiguous deletions, and some patients had deleted segments restricted to a subclone. The frequency of deletions for genes including HIVEP2 and ARID1B were higher than the corresponding number of large block deletions.