Summary of study results. (A) Copy number results per patient for the independent 30-patient validation cohort as determined by quantitative polymerase chain reaction (qPCR). Somatic MYD88 L265P and WHIM-like CXCR4 mutations were assessed in this population and annotated here for reference. The eight CNA targets selected for validation were chosen based on the 10-paired patient WGS analysis and technical validation studies. (B) Validated mutations in the 30-patient WGS cohort. Somatic status of all findings was confirmed by germline Sanger sequencing. (C) Overall frequency of validated somatic mutation (top) or CNA (bottom) for the independent 30-patient WGS and validation cohorts, respectively.