MYC/BCL2 coexpression contributes to the different gene expression profiles between GCB and ABC subtypes of DLBCL. (A) GEP comparison between the ABC vs GCB subtype of DLBCL with MYC/BCL2 coexpression. Of 157 cases of MYC⁺BCL2⁺ DLBCL, GEP was successfully performed in 149 cases (ABC: 102; GCB: 47). DP, MYC/BCL2 double positive. A total of 208 genes corresponding to 365 probe sets were differentially expressed (P < .001). (B) GEP comparison between the ABC (30 cases) vs GCB (58 cases) subtype of DLBCL negative for both MYC and BCL2 protein expression. A total of 20 genes corresponding to 30 probesets were differentially expressed between the 2 COO subtypes (P < .01). DN, MYC/BCL2 double negative.