KPT-185 induces full-length p53. OCI-AML-3 (OCI), MOLM-13 (MOLM), and MV4;11 (MV) cells were incubated with 100 nM KPT-185 for 10 hours, and expression of p53 isoforms was determined. KPT-185 increased the levels of full-length p53 (FL) in all cell lines. p53β/γ (β/γ) was barely detected in KPT-treated OCI-AML-3 and MV4;11 cells. Asterisk (*) indicates p53 fragments from full-length p53 or p53β/γ isoforms. Results are representative of 3 independent experiments. HI, high-intensity image.