Increased CRM1 expression predicts for poor survival in AML patients. (A) Three-dimensional surface plot of p53 against CRM1 and MDM2. There is a relationship between the 3 components (P = .0002), and the contour blots, projections of a three-dimensional surface onto a two-dimensional plane, demonstrate that CRM1 (positive correlation) and MDM2 level (negative correlation) interactively modulate p53 levels. The color scale refers to the expression (on the log 2 scale like the rest of the data) of the z-axis component (ie, p53). The scale of p53 ranges from <−0.5 to +2.5. The plot was generated using Statistica software. (B) Kaplan-Meier curves and results of multivariate analysis for overall survival in patients with AML. The final model of multivariate analysis includes 6 variables, and high CRM1 expression is an independent predictor of overall survival in AML.