Soluble VEGF receptors trap VEGF-A and VEGF-C and inhibit hemangiogenesis and lymphangiogenesis. Schematic representation of VEGF-A and VEGF-C (red and green, respectively) and their cognate VEGF receptors. Membrane-bound VEGF receptor (VEGFR-1, VEGFR-2, and VEGFR-3) with its seven extracellular immunoglobulin-like domains represented as circles. Critical binding domains for VEGF-A and VEGF-C of each receptor are displayed in orange. Soluble VEGF receptors (sVEGFR-1, sVEGFR-2, and sVEGFR-3) composed of the first 6 Ig-like domains and the unique C-terminus tail from alternative splicing are represented in magenta, red, and purple for sVEGFR-1, sVEGFR-2, and sVEGFR-3, respectively. Professional illustration by Alice Y. Chen.