Figure 1
Differential induction of homing molecules on allogeneic donor T cells in vivo. CFSE-labeled naive allogeneic donor T cells (B10.BR) were adoptively transferred into lethally irradiated hosts (C57BL/6), and expression of LPAM-1, E-lig, and P-lig on donor T cells was determined in spleen, liver, PLNs, and MLNs after 3 days. (A) Whereas the gut-homing molecule LPAM-1 is induced in MLNs, E-lig and P-lig are induced in PLNs (PLNs vs MLNs, *P = .002, **P < .005, ***P = .001). Expression of all molecules is intermediate in spleen and liver. Error bars represent SEM. (B) Representative example for LPAM-1 up-regulation on dividing (CFSElo) donor T cells in MLNs.
