Comparison of the effects of BMS-214662 with the cytostatic FTI BMS-225975 on quiescent CML stem/progenitor cells (n = 4). (A) The effect of BMS-225975 (250 nM) was not significantly different from the no drug control. Data are expressed as a percentage of the no drug control, and data are represented as mean plus or minus SEM. (B) Percentage of caspase-3⁺ cells in CD34⁺ CML cells (n = 6) cultured in the absence of growth factors after 24 hours of treatment with BMS-214662 or BMS-225975.