Time to first treatment according to Bax degradation activity, VH, ZAP-70 and CD38 status: Bax instability is associated with the need for early treatment. Kaplan-Meier plots of time to first treatment since diagnosis in patients classified according to (A) BDA, (B) VHmut, (C) ZAP-70, and (D) CD38 status. Cox F test was used to compare the 2 groups in each plot. N indicates number of patients; O, time of first treatment; and +, patient is untreated at time of analysis.