Survival according to Bax degradation activity, VH, ZAP-70, and CD38 status: Bax instability confers a worse prognosis. Kaplan-Meier plots of survival since diagnosis in patients classified according to (A) BDA, (B) VHmut, (C) ZAP-70, and (D) CD38 status, and also in patients with the combined markers (E) BDA⁺ and ZAP-70⁺, and (F) BDA⁺, Binet stage B or C, and CD38⁺, compared with the remainder. Cox F test was used to compare the 2 groups in each plot. n = number of patients, O indicates patient is dead, and +, patient is alive at time of analysis.