Epinephrine increases SS RBC organ sequestration. (A,B) SS RBCs were sham treated, fsk + IBMX treated, or epi treated. Sham-treated SS RBCs were detected to some degree in the lung but only minimally in the kidney. Treatment with fsk + IBMX did not significantly increase SS RBC trapping in the lung or kidney, and epi treatment led to significant increases in RBCs trapping only in the lung. Error bars show SEM of 3 different experiments. *P < .05 compared with sham-treated. The 2 parts in panel A represent 2 different experiments with similar results. (C,D) Normal RBCs were sham treated or epi treated. Epi treatment only had a significant effect on trapping of normal RBCs in the lung compared with sham-treated cells. Error bars show SEM of 3 different experiments. *P < .05 compared with sham-treated. Scale bar = 100 μm.