ABT007 dosed every 4 weeks is comparable to NESP dosed every 2 weeks. Male transgenic mice were dosed subcutaneously either with NESP (A) on days 0 and 14 or antibody (ABT007 or isotype control; B) on day 0 at the concentrations indicated. Blood samples were collected weekly, and hematocrit was measured using a HESKA Vet ABC-Diff hematology analyzer. Data represent change in hematocrit mean (± standard error) of 4 to 6 mice per treatment group. A typical NESP dose in practice is 3 μg/kg every 2 weeks.²⁶